Hyperhidrosis is defined as sweating beyond what is necessary to maintain thermal regulation.1 Localized forms (eg, axillary, hands, feet, and craniofacial) can be distinguished from generalized forms.1 In generalized hyperhidrosis (GH), anticholinergic therapy would be a logical choice because acetylcholine is the effector sudomotor neurotransmitter. However, it is a widely held opinion that there is no place for these anticholinergic agents because of their adverse effects.1 The anticholinergic drug oxybutynin is registered for pollakisuria (urination at short intervals) and hyperreflectory urine bladder. The literature on the effect of oxybutynin on hyperhidrosis is anecdotal.2 We aimed to prospectively investigate the effectiveness and adverse effects of oxybutynin therapy for GH.
Tupker RA, Harmsze AM, Deneer VHM. Oxybutynin Therapy for Generalized Hyperhidrosis. Arch Dermatol. 2006;142(8):1065-1086. doi:10.1001/archderm.142.8.1065