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August 2006

Ungueotropic T-Cell Lymphoma

Arch Dermatol. 2006;142(8):1065-1086. doi:10.1001/archderm.142.8.1071

The involvement of the nail apparatus has rarely been observed as a clinical variant of mycosis fungoides and even more rarely has it been confirmed by biopsy findings. We report a case of pilotropic T-cell lymphoma proved by histologic and molecular findings and associated with ungual involvement that is, to our knowledge, the first reported case of lymphoma-associated ungual mucinosis.

A 62-year-old man was referred to us in October 2004 with fingernail dystrophy of 2-years' duration associated with a relapse of mycosis fungoides. Since 1989, this patient had been affected by pilotropic mycosis fungoides, which was localized on his face (stage TI disease according to the TNM classification10) and had the clinical appearance of follicular mucinosis, a diagnosis confirmed by histologic and molecular findings. He had been treated with gemcitabine hydrochloride chemotherapy until 2001.