A previously healthy 24-year-old man presented to the emergency department with sudden onset of edema and erythema affecting his face, chest, and arms. The symptoms were initially attributed to a type I hypersensitivity reaction to fish curry. He was treated empirically with intravenous hydrocortisone and chlorpheniraminemaleate and was discharged home. Over the subsequent 8 hours, he developed blistering at the sites of the erythema and returned to the emergency department, where he was referred to the dermatology department.
Wain EM, Smith CH. Acute Severe Blistering in a 24-Year-Old Man—Quiz Case. Arch Dermatol. 2006;142(8):1059-1064. doi:10.1001/archderm.142.8.1059-d