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October 2006

Metastatic Hidradenocarcinoma: Efficacy of Capecitabine

Arch Dermatol. 2006;142(10):1361-1375. doi:10.1001/archderm.142.10.1366

The eccrine tumors are rare, locally aggressive neoplasms and have demonstrated a high metastatic potential. Although chemotherapy treatments have shown poor efficacy in metastatic stages, we report herein a case successfully treated with an original agent.

A 60-year-old woman presented with a metastatic hidradenocarcinoma in August 2004. The first lesion appeared in 1999 in the anterior fossa of the right elbow and was diagnosed as low-grade nodular hidradenoma. The tumor recurred many times in the following years after surgical and electron-beam treatments. Histopathologic findings were reviewed and confirmed a diagnosis of eccrine hidradenocarcinoma for all lesions excised (Figure 1).