Mycosis fungoides (MF) is a form of cutaneous T-cell lymphoma in which the neoplastic cells are epidermotropic CD3+, CD4+, CD8−, CD45RO+, and CD56− mature memory T cells. The disease generally follows an indolent course.1,2 In contrast, the CD56+ cutaneous lymphomas reported in the literature generally do not present like MF and have an aggressive disease course with a poor prognosis.3,4 We describe a patient with a clinical presentation and course consistent with MF in whom the neoplastic cells were CD2+, CD3+, CD4−, CD8−, and CD56+.
Klekotka PA, Faulkner-Jones B, Heffernan MP. A Case of CD56+ Mycosis Fungoides. Arch Dermatol. 2006;142(10):1361-1375. doi:10.1001/archderm.142.10.1370