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October 2006

Multiple Annular Plaques in an Infant—Diagnosis

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Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Dermatol. 2006;142(10):1351-1356. doi:10.1001/archderm.142.10.1351-e

Histologic sections demonstrated occasional necrotic keratinocytes within the epidermis and vacuolar alteration of the basal layer. A superficial and bandlike infiltrate of lymphocytes and histiocytes and mucin deposition were noted in the dermis. The patient's serum sample was positive for antinuclear, anti-SSA/Ro, and anti-SSB/La antibodies and negative for anti-U1RNP, anti-Smith, anti–Jo-1, and anti–Scl-70 antibodies. Her electrocardiograms revealed no abnormalities. Serologic studies of the mother's serum sample revealed anti-SSA/Ro and anti-SSB/La antibodies as well as an antinuclear antibody titer of 1:320 in a speckled pattern. The mother had no symptoms of autoimmunity.

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