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November 2006

Multiple Eruptive Angiomatous Lesions in a Patient With Multiple Myeloma—Diagnosis

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Arch Dermatol. 2006;142(11):1501-1506. doi:10.1001/archderm.142.11.1501-h

Microscopic evaluation revealed that there were several dilated vascular spaces containing groups of irregular aggregates of capillary loops, resulting in structures resembling renal glomeruli, in the upper dermis. These dilated vascular spaces were lined by a single layer of endothelial cells surrounded by pericytes and interspersed with stromal cells. The endothelial cells were characterized by intracytoplasmatic vacuoles containing multiple eosinophilic periodic acid–Schiff–positive globules. On the basis of these histopathologic features, a diagnosis of glomeruloid hemangiomas was made.

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