January 2007

Reflectance-Mode Confocal Microscopy for the Diagnosis of Sebaceous Hyperplasia In vivo

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Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Dermatol. 2007;143(1):134. doi:10.1001/archderm.143.1.134

A 54-year-old man was seen with an enlarging papule with central depression and telangiectasias on his left cheek. A clinical diagnosis of basal cell carcinoma was made with a differential diagnosis of sebaceous hyperplasia.

We investigated the use of confocal scanning laser microscopy (CSLM) to help discriminate between these diagnoses. Imaging revealed an enlarged sebaceous lobule consisting of cuboidal cells with centrally located nuclei and a dilated sebaceous duct (Figure 1). A diagnosis of sebaceous hyperplasia was made in vivo by CSLM. Excellent confocal-histopathologic correlation was obtained confirming sebaceous hyperplasia.

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