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February 2007

A Call for Papers for On the Horizon

Arch Dermatol. 2007;143(2):253-254. doi:10.1001/archderm.143.2.253

In this issue of the ARCHIVES, Woodley1 discusses new advances in our understanding of the pathogenesis of bullous pemphigoid (BP). He uses the On the Horizon section to highlight a recent study by Fairley et al2 on the role of IgE class autoantibodies in this disorder. As he notes, there is now evidence that IgE autoantibodies directed against the NC-16A domain of BP180/type XVII collagen in the basal keratinocyte hemidesmosome can mediate mast cell degranulation and eosinophil chemotaxis. These findings are important because they provide a mechanistic basis for the pruritus, urticaria, and eosinophilic spongiosis that typify early BP clinicopathologically. They are also important because they suggest new approaches for the treatment of this vexing condition.

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