The Cutting Edge article “Successful Treatment of Severe Atopic Dermatitis in a Child and an Adult With the T-Cell Modulator Efalizumab”1 in the May 2006 issue of the ARCHIVES discusses another medication for this disease with both short- and long-term potential for toxic effects added to the panoply of similar medications, including azathioprine, mycophenolate, cyclosporine, and other immunomodulators. As yet unknown adverse effects of efalizumab might preclude its long-term use. I suggest another approach to the “problem” of atopy before instituting treatments with new medications.
Rapaport M. Rebound Vasodilation From Long-term Topical Corticosteroid Use. Arch Dermatol. 2007;143(2):264-276. doi:10.1001/archderm.143.2.268-b