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February 2007

Fulminant Cutaneous Eruption in a 51-Year-Old Man—Diagnosis

Author Affiliations

Michael E.MingMD

Arch Dermatol. 2007;143(2):255-260. doi:10.1001/archderm.143.2.255-e

Biopsy specimens from the chest and right thigh revealed an atypical lymphoid infiltrate, which was associated with occasional necrotic keratinocytes and prominent hemorrhage. Markedly atypical mononuclear cells were observed within the epidermis and papillary dermis and extended well into the reticular dermis in an interstitial pattern. The cells were positive for CD3 and CD30 and negative for CD20 and CD56. The findings of direct immunofluorescence of skin samples were not diagnostic of a primary blistering disorder.

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