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Archives a Century Ago
April 2007

The Significance of Indican in the Urine of Those Afflicted With Certain Diseases of the Skin

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Arch Dermatol. 2007;143(4):454. doi:10.1001/archderm.143.4.454

“The cause of dermatitis herpetiformis is not known. It is attributed to nerve-shock, some obscure derangement of the nervous system, toxemia, disease of the bone marrow, etc. It is not the writer's intention here to enter upon a theoretical discussion of the etiology of dermatitis herpetiformis, yet if his finding of indicanuria is confirmed by further research, it seems possible that this fact might point to its principal etiological factor, namely, (1) a toxemia generated through putrefactive or other conditions in the intestines (generally the small intestines); (2) the invasion of the body by some animal parasite, the class of diseases in which it is most common to find the co-existent occurrence of indicanuria and eosinophilia. A thorough study of the stools of the these patients should be made, which has not been done in any of the cases here reported.”

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