The natural history of melanocytic nevi is poorly understood owing to the lack of follow-up studies investigating their long-term evolution. Current epidemiologic data report that the number of pigmented Spitz and Reed nevi (PSRN) peaks during the first or second decades of life, while they are rarely seen by the seventh to ninth decades.1 An explanation might be their gradual involution, but this assumption has still to be proven. We report herein 2 cases of pigmented lesions with typical clinical and dermoscopic features of PSRN that showed gradual involution at the follow-up examinations.
Argenziano G, Zalaudek I, Ferrara G, Lorenzoni A, Soyer HP. Involution: The Natural Evolution of Pigmented Spitz and Reed Nevi?. Arch Dermatol. 2007;143(4):543-551. doi:10.1001/archderm.143.4.549