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Off-Center Fold
April 2007

Papules and Plaques on the Nose—Diagnosis

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Arch Dermatol. 2007;143(4):535-540. doi:10.1001/archderm.143.4.536-d

Hematoxylin-eosin–stained sections of the specimen demonstrated an atrophic epidermis. Nodular deposits of amorphous eosinophilic material were found in the middle and deep dermis. There were prominent clefts within this material and a lymphoplasmacytic infiltrate surrounding it. A Congo red stain confirmed the presence of amyloid. The material also demonstrated apple-green birefringence on polariscopic examination. The results of systemic workup, including serum and urine protein electrophoresis, have been negative to date. Our patient is currently scheduled for carbon dioxide laser treatment of his lesions.

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