An 82-year-old white man presented with progressive, multilocalized skin lesions of more than 1 year's duration on the lower extremities (Figure, A and B) that had spread to the trunk. Histologic findings showed features of Kaposi sarcoma (KS) (Figure, C), which was confirmed by human herpesvirus 8 detection in KS and peripheral blood via polymerase chain reaction. Systemic malignancies, sarcoidosis, hypogammaglobulinemia, and dysgammaglobulinemia were excluded.
Inhoff O, Doerries K, Doerries R, Scharf J, Groden C, Goerdt S, Schadendorf D. Disseminated Cutaneous Kaposi Sarcoma and Progressive Multifocal Leukoencephalopathy in a Patient With Idiopathic CD4+ T Lymphocytopenia. Arch Dermatol. 2007;143(5):659-675. doi:10.1001/archderm.143.5.673