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Evidence-Based Dermatology: Research Commentary
June 2007

Cloud Over Sentinel Node BiopsyUnlikely Survival Benefit in Melanoma

Arch Dermatol. 2007;143(6):775-776. doi:10.1001/archderm.143.6.775

Question: Does lymphadenectomy performed for microscopic (sentinel node biopsy [SNB]) rather than macroscopic (clinically detectable) nodal disease prolong survival in patients with melanoma?

Design: Randomized controlled trial.

Setting: Multicenter trial performed in hospitals and health centers in the United States, Australia, and Europe.

Participants: A total of 1347 patients with primary melanomas of 1.2 to 3.5 mm in thickness were randomized, 20 patients were lost after randomization, and the remaining 1327 were from North America (n = 221), Europe (n = 386), and Australia (n = 720), with 1269 patients finishing the study. Study groups had similar baseline characteristics, and patients were randomly assigned to SNB or observation in a 60:40 ratio.

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