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June 2007

The Role of the QuantiFERON-TB Gold Test as Screening Prior to Administration of Tumor Necrosis Factor Inhibitors

Arch Dermatol. 2007;143(6):799-816. doi:10.1001/archderm.143.6.809

A 35-year-old man with palmar-plantar psoriasis tested positive for tuberculosis with a tuberculin skin test (TST) prior to starting etanercept therapy. He had not received a BCG vaccination and denied contact with infected people or traveling to tuberculosis-endemic areas. Two subsequent TSTs showed negative results, and a chest radiograph was normal. One month after the last negative TST finding, a QuantiFERON-TB Gold (QFT-G) test (Cellestis Inc, Carnegie, Australia) was performed, and the results were negative. Twelve months after starting etanercept treatment, he showed improvement of his psoriasis and had no evidence of tuberculosis.

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