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July 2007

Diffuse Cutaneous Nodules—Diagnosis

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Arch Dermatol. 2007;143(7):937-942. doi:10.1001/archderm.143.7.937-g

Microscopic examination demonstrated numerous glandular structures composed of atypical cells in the dermis (Figures 2 and 3). Immunohistochemical stains were positive for prostate-specific antigen and negative for cytokeratin AE1/AE3. Thus, the histologic findings were consistent with cutaneous metastasis of prostate cancer. Further investigations revealed extensive metastases to the brain, bladder, bones, and skin. The patient underwent palliative bilateral orchiectomy and radiation therapy to the cervical spine, thoracic spine, and right clavicle. He died 17 days after admission following an acute change in mental status.

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