February 1, 2008

Severe Purpuric Xerotic Dermatitis Associated With Gefitinib Therapy

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Dermatol. 2008;144(2):269-270. doi:10.1001/archdermatol.2007.53

Gefitinib (Iressa; AstraZeneca, London, England) has been used in the treatment of non–small cell lung cancer (NSCLC).1 The cutaneous toxic effects associated with epidermal growth factor receptor (EGFR) inhibitors are follicular eruption, paronychia, and xerosis.24 Herein, we describe 3 patients with reticular erythematous eruptions on the lower extremities associated with gefitinib.

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