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February 1, 2008

Severe Purpuric Xerotic Dermatitis Associated With Gefitinib Therapy

Arch Dermatol. 2008;144(2):269-270. doi:10.1001/archdermatol.2007.53

Gefitinib (Iressa; AstraZeneca, London, England) has been used in the treatment of non–small cell lung cancer (NSCLC).1 The cutaneous toxic effects associated with epidermal growth factor receptor (EGFR) inhibitors are follicular eruption, paronychia, and xerosis.24 Herein, we describe 3 patients with reticular erythematous eruptions on the lower extremities associated with gefitinib.

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