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July 21, 2008

Eroded Patch on the Nipple of a 57-Year-Old Woman—Diagnosis

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Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Dermatol. 2008;144(7):933-938. doi:10.1001/archderm.144.7.934-a

Microscopic examination of the diagnostic shave biopsy specimen revealed an endophytic epithelial neoplasm arising from the base of the epidermis. The lobules of epithelial cells invading the dermis variably exhibited either a glandular or solid morphology. Decapitation secretion was present. An immunoperoxidase stain for smooth muscle actin confirmed the presence of an outer myoepithelial cell layer on the proliferating ductal epithelium. The histological and immunohistochemical findings were consistent with a diagnosis of EAN. Complete excision was achieved with Mohs micrographic surgery. The tissue-sparing benefits allowed for immediate aesthetic reconstruction of the nipple.

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