Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008
In the August 2007 issue of the Archives, Legat et al1 described the accelerated and improved clearance of psoriasis when alefacept is combined with narrowband (NB) UV-B phototherapy. Because all patients in this study were treated with alefacept and with a randomly selected body half exposed to NB UV-B phototherapy, the question remained as to whether the improvement seen was greater than what can be achieved with NB UV-B monotherapy. We present data from 16 patients with chronic plaque psoriasis requiring systemic or phototherapy who were enrolled in an institutional review board approved, randomized, double-blind, placebo-controlled study comparing alefacept with NB UV-B vs NB UV-B alone for the treatment of psoriasis.
Jacobe H, Winterfield L, Kim F, Huet-Adams B, Cayce R. The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis. Arch Dermatol. 2008;144(8):1067-1068. doi:10.1001/archderm.144.8.1067