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November 17, 2008

Hyperpigmented Patches on the Trunk of a Nigerian Woman—Diagnosis

Author Affiliations


Arch Dermatol. 2008;144(11):1509-1514. doi:10.1001/archderm.144.11.1509-h

Histopathologic examination of the specimen showed compact orthohyperkeratosis with rare parakeratosis. The epidermis was slightly thickened, with some melanin in the stratum corneum, a diminished granular cell layer, and an intact basal cell layer with uniform pigmentation. There was mild papillary dermal fibrosis and a mild perivascular lymphocytic infiltrate. Fungal stains (periodic acid–Schiff and Gomori methenamine silver) were negative.

The patient responded remarkably well to topical treatment with 12% lactic acid lotion. The lung opacities resolved without specific treatment.

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