The patient, a man forty-nine years of age, had called on Dr. Trimble about three weeks previously, with what seemed to be herpes progenitalis. He also exhibited two bullous lesions on the trunk, about the size of a twenty-five-cent piece, surrounded by an inflammatory areola; and several collapsed bullæ around the anal margin. The lesions at that time had existed for three days, and were without subjective symptoms, with the exception of those on the foreskin. These latter caused itching and burning. As the cutaneous condition on the body did not conform to any well-known dermatosis, the man was questioned as to whether he had taken any drug, and it developed that he had taken nothing but a dose of quinine for a “cold.” He was given some simple treatment, and the condition rapidly disappeared. On account of the rarity of bullous lesions following the administration of quinine, a test was decided upon. Two days ago, the patient was given five grains of quinine, and the next day the cutaneous manifestation reappeared. They were vesicular on the prepuce, but erythematous on the body. The case was shown on account of a bullous dermatitis following quinine; and two other interesting features were, that the lesions were of the same size and in exactly the same locations as in the previous outbreak.
Dermatitis Medicamentosa (Quinine). Presented by Dr. Trimble.. Arch Dermatol. 2010;146(4):368. doi:10.1001/archderm.146.4.368