MICHAELBIGBYMDOLIVIERCHOSIDOWMD, PhDROBERT P.DELLAVALLEMD, PhD, MSPHDAIHUNGDOMDURBÀGONZÁLEZMD, PhDCATALIN M.POPESCUMD, PhDHYWELWILLIAMSMSc, PhD, FRCP
Thank you for this commentary on our article “Effects of a Cosmetic ‘Anti-ageing’ Product on Photoaged Skin.”1 We wish to address the individual points raised in the commentary.
In our article, we used an occluded patch test on photoaged extensor forearm skin to assess the potential of topical agents to repair photoaged skin. Such agents would include cosmetic (ie, over-the-counter, nonmedicinal, and nonprescribed) creams. The assay is designed to examine the modulation of histologic abundance and distribution of fibrillin-rich microfibrils, key components of the skin's elastic fiber network, in the papillary dermis of photoaged human skin.2 The assay allows the evaluation of emerging treatments or products compared with occlusion with the clinical gold standard treatment, all-trans retinoic acid (tretinoin), our positive control. This is an important point and one that has been misreported in the commentary.
Watson REB, Griffiths CEM. Effects vs Improvement of Photoaged Skin—Reply. Arch Dermatol. 2010;146(5):549-550. doi:10.1001/archdermatol.2010.70