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May 2010

Permanent Localized Hair Repigmentation Following Herpes Zoster Infection

Author Affiliations

Author Affiliations: New York Medical College, Valhalla (Drs Adiga, Rehman, and Wiernik); and Montefiore Medical Center North Division, Bronx, New York (Drs Adiga and Rehman).

Arch Dermatol. 2010;146(5):569-570. doi:10.1001/archdermatol.2010.82

In 1999, a 92-year-old Hispanic man was diagnosed as having localized prostate cancer with a Gleason score of 7. His prostate-specific antigen (PSA) level was 34 ng/mL. (To convert PSA to micrograms per liter, multiply by 1.0.) Initially, his case was managed with watchful waiting for 3 years. In 2002, owing to increasing PSA levels (82 ng/mL), he began androgen-deprivation therapy (ADT) with goserelin, 3.6 mg, subcutaneously every 4 weeks.

In July 2004, he developed a severe herpes zoster infection involving the ophthalmic branch of the right trigeminal nerve with a vesicular rash that required hospitalization. Findings from laboratory studies including complete blood cell counts, chemical analyses, and liver function tests were within normal limits. He was treated with acyclovir, 500 mg, intravenously every 8 hours, but the dose was later increased to 700 mg on the fourth day of hospitalization. His other medications included trifluridine ophthalmic drops, bicalutamide, doxazosin, enalapril, and amlodipine.

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