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July 2010

Value of the Detection of Circulating Antibodies Against BP Antigens in Unaffected Subjects—Reply

Author Affiliations

Author Affiliation: Departments of Medicine (Dermatology) and Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Arch Dermatol. 2010;146(7):801-802. doi:10.1001/archdermatol.2010.138

In reply

When used as a diagnostic marker of bullous BP, the detection by ELISA of autoantibodies against either of the 2 BP antigens (BPAG1 or BPAG2) in the absence of clinical evidence of disease must be considered to be a false-positive finding, by definition, even though these autoantibodies can be shown to bind to purified antigen. However, such a finding may prove clinically relevant, as opposed to representing an epiphenomenon, if the presence of either autoantibody can be shown to predict who might later develop BP.

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