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July 2010

Ulcerated Plaque on the Chin of a Young Woman—Diagnosis

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Arch Dermatol. 2010;146(7):789-794. doi:10.1001/archdermatol.2010.151-b

Histopathologic examination of the biopsy specimen showed epidermal hyperplasia with a diffuse superficial and deep inflammatory infiltrate and pseudoepitheliomatous epidermal hyperplasia with a predominantly lymphocytic dermal infiltrate and parasitized macrophages (Figure 2, original magnification ×40). There were numerous 2- to 4-μm round to oval organisms, with kinetoplasts located at the periphery of vacuolated cytoplasm of macrophages, consistent with amastigotes (Figure 3), original magnification ×600). These findings supported the diagnosis of cutaneous leishmaniasis, eventually speciated as Leishmania panamensis.

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