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July 2010

Papulonodular Eruption, Proteinuria, and Peripheral Arthritis—Diagnosis

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Arch Dermatol. 2010;146(7):789-794. doi:10.1001/archdermatol.2010.152-b

Histologic findings of the lesion demonstrated disordered, fragmented collagen bundles in the dermis with a scant lymphocytic infiltrate. The overlying epidermis was normal. Elastin von Gieson staining revealed normal elastin fibers. Alcian blue staining demonstrated increased mucin at the site of the disordered collagen bundles. The patient began treatment with sulphasalazine prescribed by a rheumatologist. While the sulphasalazsine treatment controlled the arthritis, it had no effect on the papules.

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