A melanotic lentigo maligna (ALM) represents a small subset of lentigo maligna (LM) that lacks pigment. At least 2 cases of ALM responsive to imiquimod therapy with short-term follow-up have been reported.1 We report herein a case of ALM that failed to respond to imiquimod treatment. Furthermore, after therapy was initiated, the ALM began to produce pigment and transformed to LM.
Martires KJ, Capaldi L, Pattee SF, Maloney ME, Bordeaux JS. Failed Treatment of Amelanotic Lentigo Maligna With Imiquimod Followed by Pigment Production. Arch Dermatol. 2010;146(9):1047-1048. doi:10.1001/archdermatol.2010.237