A 71-year-old woman with a history of aspirin allergy and asthma assisted her husband (diagnosed as having xerosis and Grover disease) by applying salicylic acid, 6%, lotion and pramoxine-hydrocortisone, 2.5%, lotion to his back, where he could not reach himself. Within 30 minutes thereafter, she was sneezing and coughing and needed to use her fluticasone-salmeterol inhaler, which led to resolution of her symptoms about 10 hours later. This problem did not recur once she read the ingredients of the moisturizing lotion and opted to no longer help her husband with topical salicylic acid. His treatment regimen was later switched to topical ammonium lactate, 12%, lotion for his xerosis to avoid the problem in future.
Heymann WR. Caregiver Hypersensitivity. Arch Dermatol. 2010;146(9):1048-1049. doi:10.1001/archdermatol.2010.227