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September 2010

Mondor Disease in a Patient With Psoriasis Treated With an Anti–Interleukin 12/Interleukin 23 Investigational Drug

Author Affiliations

Author Affiliations: Virginia Clinical Research Inc, Dermatology (Dr Hirano), and Department of Dermatology, Eastern Virginia Medical School (Drs Mason, Warthan, and Pariser), Norfolk.


Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Dermatol. 2010;146(9):1049-1050. doi:10.1001/archdermatol.2010.232

A 61-year-old male participant in a psoriasis clinical trial was seen with a 1-week history of cordlike bands over his left thoracoabdominal wall, which became rapidly painful 1 day prior to our seeing him. He noted the cordlike bands 2 months after beginning weekly treatment with subcutaneous injections of either an investigational monoclonal antibody to interleukin 12 (IL-12)/IL-23 or of placebo. The pain was exacerbated by left arm abduction and trunk rotation.

On physical examination, we found discrete linear and indented erythematous cordlike bands in a branching pattern along the vertical anterolateral chest wall (Figure 1). Tenderness was elicited on palpation of the lesions. The patient had no prior similar episodes and no personal or family history of coagulopathy. A diagnosis of Mondor disease was suspected. The pain resolved within a few weeks, and the cordlike bands resolved within 1 to 2 months.

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