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September 2010

Skin Nodules in a Patient With Acute Myeloid Leukemia and Neurological Deterioration—Diagnosis

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Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Dermatol. 2010;146(9):1037-1042. doi:10.1001/archdermatol.2010.216-b

Histopathologic examination revealed septated hyphae with acute angle branching within vessels, consistent with septic emboli. Invasion into the vessel walls and perivascular tissue was identified, although the overlying epidermis was unremarkable. Concurrent tissue culture grew Fusarium the following day. The patient, who had been receiving voriconazole prophylaxis since admission, was then started on therapy with liposomal amphotericin B. Unfortunately, during the subsequent days, he continued to develop new lesions, his neurological status rapidly declined, and he died.

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