A 47-year-old woman was seen with a 2-year history of a solitary 1.0 × 0.7-cm yellowish papule on the face (Figure 1A). Histopathologic examination revealed irregular sebaceous lobules with peripheral lining of the basaloid cells in the dermis (Figure 2A and B). The lesion was treated with photodynamic therapy (PDT). Methyl aminolevulinate (MAL) (Metvix; Galderma, Paris, France) was applied to the lesion and covered with occlusive film. After 3 hours, the lesion was irradiated with red light from a Waldman (Wheeling, Illinois) PDT 1200 lamp (light dose, 100 J/cm2; fluence, 100 mW/cm2). The PDT therapy was repeated 3 times at 4-week intervals. Eight months after the last treatment, a second biopsy specimen was obtained. Although the lesion showed marked clinical improvement (Figure 1B), the sebaceous lobules with proliferation of basaloid cells were still present (Figure 2C and 2D).
Kim SK, Lee JY, Kim YC. Treatment of Sebaceous Adenoma With Topical Photodynamic Therapy. Arch Dermatol. 2010;146(10):1186-1188. doi:10.1001/archdermatol.2010.278