[Skip to Content]
[Skip to Content Landing]
April 2011

Two Novel H-RAS Mutations Identified in a Child With an Atypical Spitzoid Tumor

Author Affiliations

Author Affiliations: Clinical Physiopathology, Clinical Biochemistry Unit (Mss Simi, Pinzani, and Salvianti and Messrs Orlando and Pazzagli), and Department of Critical Care Medicine and Surgery, Division of Pathological Anatomy (Dr Lorenzoni and Massi), University of Florence, Florence, Italy; and Department of Medical Sciences and Human Oncology, Dermatology Section, University of Turin, Turin, Italy (Drs Tomasini and Broganelli).

Arch Dermatol. 2011;147(4):514-515. doi:10.1001/archdermatol.2011.76

A 9-year-old white girl presented with a rapidly growing pigmented papule, 6 × 5 mm, on her right leg (Figure 1A). Dermoscopy showed peripheral irregular streaks, a blue-whitish veil, and a central homogeneous yellowish hue (Figure 1B). The lesion was surgically removed. Histopathologic examination showed a dome-shaped compound spitzoid melanocytic proliferation extending into the dermis up to 1 mm in thickness (Figure 1C). Melanocytes were mostly arranged in confluent aggregates featuring a nodular dermal growth (Figure 1D). Mitotic rate was 2 mitoses/mm2. The histopathologic diagnosis was atypical spitzoid tumor (AST) with free margins. No further treatment was performed, and the patient was alive with no further evidence of disease at 10-year follow-up.

First Page Preview View Large
First page PDF preview
First page PDF preview