The Cutting Edge: Challenges in Medical and Surgical Therapies
June 20, 2011

Efficacy of Intravenous Cidofovir in the Treatment of Giant Molluscum Contagiosum in a Patient With Human Immunodeficiency Virus

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Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Dermatol. 2011;147(6):652-654. doi:10.1001/archdermatol.2011.20

Molluscum contagiosum virus (MCV) is a DNA virus in the Poxviridae family that may cause extensive and voluminous lesions often resistant to topical therapies in patients with AIDS and other immunocompromised patients. We present a case of eruptive giant molluscum that caused remarkable deformity in a patient with AIDS. Intravenous (IV) cidofovir was used as therapy, resulting in dramatic improvement.

A 43-year-old man who had tested positive for human immunodeficiency virus (HIV) presented to our clinic with a CD4 count of 32 cells/μL 4 months after starting highly active antiretroviral therapy (HAART). He had a 1-year history of eruptive nodules on his scalp, face, neck, and groin, and the nodules were increasing in size and number despite topical therapies. Physical examination revealed multiple erythematous to skin-colored exophytic, globose nodules on his head, neck, hands, and groin. Two shave biopsy specimens were obtained, and histologic findings were consistent with MCV.

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