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February 2011

Bullous Fixed Drug Eruption Induced by Intravaginal Metronidazole Ovules, With Positive Topical Provocation Test Findings

Author Affiliations

Author Affiliations: Department of Dermatology, Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.

Arch Dermatol. 2011;147(2):250-251. doi:10.1001/archdermatol.2010.419

A 35-year-old woman was seen with skin lesions that had developed over the past 48 hours. She had 5 erythematous, highly pruriginous oval patches, 4 to 6 cm in diameter, localized on her neck, trunk, and arms. Some lesions showed incipient blistering and acquired an intense erythematous, nearly purpuric color (Figure 1). Three of the 5 macules appeared over a hyperpigmented area from a previous episode secondary to metronidazole intake. A fixed drug eruption (FDE) was diagnosed.

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