A 22-year-old man was seen with more than a dozen painless papules and nodules located on the thorax and limbs, present since infancy. New lesions appeared regularly. Several family members were affected by similar lesions. Genetic analysis confirmed a diagnosis of glomangiomatosis. A test session with 595-nm pulsed-dye laser (PDL) at 7-mm spot size, 20-millisecond intervals, and 12 J/cm2 fluency was performed on 1 lesion, and 1064-nm Nd:YAG laser, 3-mm spot size, 40-millisecond intervals, and 240 J/cm2 fluency was used on another. One month later, the lesion treated by PDL had decreased in size by 50%, while the lesion treated by Nd:YAG laser had almost completely cleared. Remaining lesions were treated with Nd:YAG laser using the same parameters used in the test lesion. After 2 sessions, all lesions had cleared. Follow-up at 1 year showed no recurrence of the treated lesions.
Hughes R, Lacour J, Chiaverini C, Rogopoulos A, Passeron T. Nd:YAG Laser Treatment for Multiple Cutaneous Glomangiomas: Report of 3 Cases. Arch Dermatol. 2011;147(2):255-256. doi:10.1001/archdermatol.2010.437