Coal tar, a mixture of at least 10,000 components, has long been shown to have efficacy in the treatment of psoriasis.1 Exorex (IMX Pharmaceuticals Inc, Boca Raton, Fla) is a new coal tar–based, Food and Drug Administration–sanctioned psoriasis medication deemed safe for sensitive skin. Calcipotriene (Dovonex; Westwood-Squibb Pharmaceuticals, Buffalo, NY) is an active cholecalciferol analog, useful in psoriasis therapy, but which can cause dermatitis in sensitive areas.2 We conducted a pilot study comparing the therapeutic efficacy and safety of Dovonex (hereinafter, "calcipotriene") and Exorex (hereinafter, "1% coal tar emulsion") in treating psoriasis.
Veronikis IE, Malabanan AO, Holick MF. Comparison of Calcipotriene (Dovonex) With a Coal Tar Emulsion (Exorex) in Treating Psoriasis in Adults: A Pilot Study. Arch Dermatol. 1999;135(4):474-a-475. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-4-dlt0499