We appreciate the interest of Weisshaar et al in our case report.1 The answers to points they raise are as
We found the account of the commentators' previous experimental work and complementary case report very interesting. Our case report demonstrates that ondansetron has provided a sustained clinical benefit without adverse effects for a difficult management problem of localized pruritus and is worth considering in such situations.
Downs AMR, Kennedy CTC. Antipruritic Potency of Serotonin Type 3 (5-HT3) Receptor Antagonists—a Reply. Arch Dermatol. 1999;135(5):600. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-5-dlt0599