Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999
Microscopically, the lesion consisted of a subepithelial blister full of unclotted hemorrhagic material, surrounded by a granulation tissue with a chronic inflammatory infiltrate. The surface epithelium was slightly flattened. The findings of direct immunofluorescence were negative.
The term angina bullosa haemorrhagica was first used by Badham1 in 1967 to describe blood blisters occurring in the oral, pharyngeal, and esophageal mucosa that seemed to be unrelated to an identifiable cause or systemic disorder. Badham also cited previous reports that were probably dealing with the same condition and suggested that ABH probably occurs more commonly than the literature indicates. Hopkins and Walker2 and later Stephenson et al3 described 2 series of patients with similar characteristics, helping to establish ABH as a well-defined entity.
Recurrent Oral Blood Blisters. Arch Dermatol. 1999;135(5):593-a-598. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-5-dof8025