Histologically, the lesion consisted of basaloid tumor islands embedded in a fibrous stroma and demonstrating retraction artifact. Some of these tumor islands were connected to the overlying epidermis.
The pathogenesis of BCC is most associated with prolonged exposure to sunlight. Thus, the vast majority of BCCs occur on the head and neck (85%), although a significant number also occur on the trunk and extremities.1,2 Basal cell carcinomas of the palm are rare and have been found mainly in patients with the nevoid BCC syndrome.3 However, sporadic cases have been reported in patients who were exposed to arsenic and radiation4; 1 case was reported in a patient with chronic scarring from epidermolysis bullosa dystrophica5 and 1 in a patient at a site of previous trauma from a wood splinter.6 To our knowledge, there have been only 6 reported cases of isolated BCC of the palm since the first reported case in 1960.7
A Slowly Growing Tender Plaque of the Palm. Arch Dermatol. 1999;135(6):707-712. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-6-dof0699