Vulvar melanosis (VM) clinically may mimic malignant melanoma (Figure 1), but histologically lacks substantial melanocytic proliferation or atypia. Key histopathologic findings include basal cell layer hyperpigmentation with occasional acanthosis and pigment incontinence (Figure 2, top).1 The origin of these lesions is unknown, and the clinical significance is relatively unclear. Because human papillomavirus (HPV) is involved in the pathogenesis of many anogenital lesions and specific HPV types have been correlated with pigmented lesions,2
we investigated whether HPV could also play a role in VM.
Jih DM, Elder DE, Elenitsas R. A Histopathologic Evaluation of Vulvar Melanosis. Arch Dermatol. 1999;135(7):857-858. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-7-dlt0799