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Off-Center Fold
July 1999

Discoid Lupus Erythematosus–Like Lesions and Stomatitis

Arch Dermatol. 1999;135(7):845-c-850. doi:10-1001/pubs.Arch Dermatol.-ISSN-8503-987x-135-7-dof0799

Microscopic examination of the skin sample revealed hyperkeratosis and a lichenoid mononuclear cell infiltrate in the superficial dermis, with extension around the blood vessels in the deeper reticular dermis. Direct immunofluorescence showed IgM and C3 deposits along the basement membrane.

The analysis of the patient's neutrophil function by means of the burst test showed that 50% of the cells were unable to synthesize hydrogen peroxide and superoxides. The same dysfunction was present in 100% of the son's neutrophils, whereas those of his father were absolutely normal. On this basis, it was concluded that the patient was a carrier of the chromosome X-linked chronic granulomatous disease.

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