A 65-year-old woman presented with a painful nodule on the lower part of her right leg. She stated that the nodule had enlarged and become more red over the past 6 months. Her general health was good; she specifically denied weight loss or night sweats. The cutaneous examination showed a soft 6×7-cm, yellow-green tumor on her skin (Figure 1). On palpation, the tumor was movable. The findings of the physical examination were otherwise unremarkable; no inguinal lymph nodes were palpable. The results of laboratory tests were all within normal units. The tibia and fibula were normal on radiological examination. Ultrasound evaluation of the regional lymph nodes and abdomen revealed no abnormalities. A deep biopsy specimen was obtained (Figure 2 and Figure 3).
Biedermann TM, Schirren CG. Subcutaneous Nodule of the Lower Extremity. Arch Dermatol. 1999;135(9):1113-1118. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-9-dof0999