[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 1999

Successful Treatment of Resistant Hypertrophic and Bullous Lichen Planus With Mycophenolate Mofetil

Author Affiliations

Not Available

Arch Dermatol. 1999;135(11):1420-1421. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-11-dlt1199

Mycophenolate mofetil is an immunosuppressive drug that has recently been used to treat autoimmune and inflammatory skin diseases.1,2 We herein report the first case of lichen planus (LP) successfully treated with mycophenolate.

A 55-year-old white woman with a 10-year history of LP of the lower extremities presented for a therapeutic alternative. Prior treatments included several courses of tapered oral and topical steroids, including a 9-week course of flurandrenolide tape applied nightly, psoralen–UV-A, hydroxychloroquine sulfate (400 mg/d for 10 months), azathioprine (150 mg/d for 8 months), and methotrexate (15 mg/wk for 7 months), none of which led to sustained improvement. On physical examination, she had multiple hypertrophic scaly papules and plaques on the pretibial areas bilaterally, some of which were ulcerated. On the medial aspects of the feet, she had violaceous bullous plaques. No mucosal lesions were present. Histological examination of the hypertrophic and bullous lesions demonstrated changes characteristic of LP.

First Page Preview View Large
First page PDF preview
First page PDF preview