The skin biopsy specimen showed a normal epidermis and an inflammatory infiltrate in the middle and deep dermis. There was a perivascular and interstitial infiltrate composed of lymphocytes, neutrophils, histiocytes, and rare multinucleated giant cells. No collagen sclerosis or palisading granulomas were identified. An alcian blue stain did not reveal increased mucin deposition. The histopathologic findings were compatible with the interstitial variant of granuloma annulare. The clinical differential diagnosis included lichen planus, mucinosis, and amyloidosis. These entities with well-defined pathologic features were easily ruled out by the histopathologic findings. Some of the lesions spontaneously resolved without therapeutic intervention.
A Generalized Papular Eruption. Arch Dermatol. 1999;135(11):1409-a-1414. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-11-dof9021