In an interesting article "Response of Murine and Normal Human Skin to Injection of Allogeneic Blood-Derived Psoriatic Immunocytes," Nickoloff et al1 present an innovative idea that immunocytes expressing receptors of natural killer (NK) cells play a possible role in the pathogenesis of psoriasis. The authors suggest that the inhibitory receptors on NK cells (killer cell inhibitory receptors [KIRs]) may prevent NK T-cell–induced lysis of self major histocompatibility complex (MHC) class I–bearing target cells while killer cell activating–receptors (KARs) may activate NK T-cell cytotoxicity and probably contribute to the damage of the epidermal basement membrane in the early stages of disease.
Jablonska S, Majewski S. On the Immunopathogenesis of Psoriasis. Arch Dermatol. 2001;137(2):229-230. doi: