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February 2001

Lisch Nodules and Skin Manifestation in Neurofibromatosis Type 1

Arch Dermatol. 2001;137(2):232-233. doi:

Neurofibromatosis type 1 (NF1) develops various neurocutaneous manifestations in patients at various ages.1 It has been suggested that Lisch nodules or pigmented iris hamartomas appear in infancy or early childhood2; however, the frequency of their appearance has been reported to range from 56% to 97% in patients with NF1; there is great discrepancy among these reports.3,4 Since Lisch nodules are usually asymptomatic, little information is available on their clinical behavior.

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