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March 2001

Use of Minocycline and Soft Tissue Pigmentation: Close Association

Arch Dermatol. 2001;137(3):372. doi:

With great interest I read the Vignette by Tanzi and Hecker1 in the March 2000 issue of the ARCHIVES, in which the authors state that only 2 cases of lingual hyperpigmentation associated with minocycline have been reported.2 However, my colleagues and I were the first to report a similar case in 1995, also in the ARCHIVES.3 In our case, the onset of the pigmentation occurred after only 1 week of treatment with a high dose of minocycline (300 mg/d), and the resolution of this symptom took place 3 weeks after discontinuation of the drug treatment. This might reflect a dose-response effect. I believe that if patients receiving minocycline therapy would undergo a routine oral examination, the rate of reported pigmentation of the soft oral tissue after the use of this drug would be much higher.

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