A skin biopsy specimen revealed dermal nodules of anastomosing vascular channels within a myxoid stroma, and consisted of cords of rounded or polygonal epithelioid endothelial cells with abundant eosinophilic cytoplasm; atypical, large, hyperchromatic nuclei; and prominent intracytoplasmic vacuoles. Intraluminal erythrocytes were identified, and a few mitotic figures were noted. Tumor cells expressed cytokeratin as well as CD31 and CD34. Based on the clinical and morphological features, a diagnosis of EHE was rendered. The microscopic features of the original excision were also thought to be consistent with that diagnosis.
Recurrent Papules on the Left Upper Extremity of a 50-Year-Old Man. Arch Dermatol. 2001;137(3):365-370. doi: